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USACM Large-Scale TTA Early-Career Colloquium (virtual)
Wednesday, December 01, 2021, 1:00 PM - 2:00 PM CST
Category: Events

USACM Large-Scale TTA Early-Career Colloquium (virtual)

Multiphysics Modeling of Biological Flows with Cell Suspensions

Jifu Tan
Northern Illinois University



Fluid flows containing solid particles are common in engineering and biology, e.g., complex flow with cellular suspensions. The dynamic behavior in such phenomena is complex and poorly understood due to interactions between individual particles as well as interactions between the particles and the surrounding fluid and bounding walls. Moreover, the presence of highly deformable particles, such as blood cells, vesicles and polymers, make it particularly challenging to accurately describe the dynamics in such systems. In this presentation, a massively parallel Multiphysics simulation platform developed on popular open-source code will be introduced to simulate such complex flows. The fluid flow was solved by the Lattice Boltzmann method (LBM), while the solid deformation and diffusion were simulated by particle-based solver. The coupling was achieved through the immersed boundary method (IBM) so that different physics can exchange information with each other. The developed simulation framework was validated with various analytical solutions and experiments and shown to scale almost linearly over thousands of processors. Applications are given in drug delivery, cancer cell detection in microfluidics, and blood flow in a retina vascular network, demonstrating an efficient way of simulating coupled multi-physics problems.


Dr. Jifu Tan currently is an assistant professor in Mechanical Engineering at Northern Illinois University. Before that, he was a postdoctoral associate in the Department of Chemical and Biomolecular Engineering at the University of Pennsylvania. He obtained his Ph.D. and M.S. in Mechanical Engineering from Lehigh University in 2015 and 2012, respectively. He received his B.S. degree in Civil Engineering from Beijing Jiaotong University in 2007. His primary research interest is fluid structure interaction and its application in engineering and medicine, such as nanoparticle delivery, blood flow modeling, thrombosis and bleeding simulation, microfluidic device design for cell separation. He is also interested in high performance computing, multiscale modeling, and data driven models. He is actively engaged in developing open-source code for scientific research.

Sponsored by USACM Technical Thrust Area on Large Scale Structural Systems and Optimal Design.
Contact for information about the seminar: [email protected]